Murguía has devoted her career to public service. She began her career in Washington, DC as legislative counsel to former Kansas Congressman Jim Slattery. She then worked in the White House from 1994 to 2000, ultimately serving as deputy assistant to President Clinton, providing strategic and legislative advice to the president on key issues. In 2001, Murguía joined the University of Kansas (KU) as executive vice chancellor for university relations. She grew up in Kansas City, Kansas. Murguía is currently a Board member of Achieve, an independent and nonpartisan nonprofit education reform organization, and the Hispanic Association for Corporate Responsibility. She also serves as a member of Diversity Advisory Councils for Bank of America, Charter Communications, Comcast/NBC Universal, and Wells Fargo. She received three degrees from KU: a B.S. degree in journalism, a B.A. degree in Spanish, and a J.D. from the KU School of Law.