Huber has a long history of promoting abstinence-only programs. She has worked to limit comprehensive sex education at the state level in Ohio during her decade with Ascend (formerly called the National Abstinence Education Association), and was at the federal and international levels within the Department of Health and Human Services (HHS). After several positions at HHS — including a stint steering HHS’s family planning funds — in January 2019 the Trump-Pence administration moved Huber to its Office of Global Affairs, which coordinates diplomacy and related efforts on health with other countries. Now, Huber works to promote the Geneva Consensus Declaration internationally, and has founded in 2021 the Institute for Women's Health and is its director.