Harris is CEO and managing partner of Vesalius Ventures, a venture capital firm. He is a former NASA astronaut who was mission specialist on the space shuttle Columbia in 1993 and a payload commander on the space shuttle Discovery in 1995. He became the first African American to walk in space. He is a member of the board of U.S. Physical Therapy and Monebo Technologies, as well as the National Academies of Science, Engineering and Medicine.