The Sentinal has three distinct coordinating centers: Sentinel Operations Center, Innovation Center, and Community Building and Outreach Center. Operations Center - Leverages partnerships in the areas of epidemiology, clinical medicine, pharmacy, statistics, health informatics, data science (specifically, artificial intelligence (natural language processing, machine learning)), and network operations to support postmarket safety analyses. Innovation Center- Develops methods to further advance Sentinel, including exploring novel ways to extract and structure information from electronic health records Community Building and Outreach Center - Focuses on communication and collaboration deepening stakeholder involvement