His prodigiously observant, exuberantly plotted, grammatically and etymologically challenging, philosophically probing and culturally hyper-contemporary novels, stories and essays made him an heir to modern virtuosos like Thomas Pynchon and Don DeLillo, an experimental contemporary of William T. Vollmann, Mark Leyner and Nicholson Baker and a clear influence on younger tour-de-force stylists like Dave Eggers and Jonathan Safran Foer. Mr. Wallace’s wife, Karen Green, returned home to find that her husband had hanged himself. Mr. Wallace’s father, James Donald Wallace, said in an interview on Sunday that his son had been severely depressed for a number of months. Mr. Wallace, who had taught creative writing at Pomona College in Southern California since 2001 and before that had taught at Illinois State University, came to prominence in 1986 with a broadly comic first novel, “The Broom of the System” (Viking), published when he was just 24. Mr. Wallace was born in Ithaca, N.Y., where his father was a graduate student in philosophy. When David was 6 months old, his father got a job at the University of Illinois, and the family moved to Champaign, Ill., where David became a locally prominent junior tennis player. At Amherst College, he studied philosophy and English, graduating summa cum laude in 1985. In addition to his wife, whom he married in 2004, and his parents, who live in Urbana, Ill., Mr. Wallace is survived by a sister, Amy Wallace Havens of Tucson.