He saw his previous firm, FlatIron Partners, nearly fold in Web 1.0. Now with the help of his popular blog, A VC, Wilson has become the VC face of Web 2.0. His blog garners more than 50,000 visits a week, and one post can generate upward of 500 comments--and, occasionally, investment ideas. Wilson got the ideas to invest in FeedBurner, Zemanta and Twitter from user comments. His early stage investments in ComScore (went public), Tacoda (sold to AOL), Etsy, Zynga and Twitter propel him right up our list.