Sir John M. Templeton, a Tennessee-born investor and philanthropist who amassed a fortune in global stocks and gave away hundreds of millions of dollars to foster understanding in what he called “spiritual realities,” died Nassau, the Bahamas, where he had lived for decades. His foundation awards the Templeton Prize, one of the world’s richest, and sponsors conferences and studies reflecting the founder’s passionate interest in “progress in religion” and “research or discoveries” on the nebulous borders of science and religion. In a career that spanned seven decades, Sir John dazzled Wall Street, organized some of the most successful mutual funds of his time, led investors into foreign markets, established charities that now give away $70 million a year, wrote books on finance and spirituality and promoted a search for answers to what he called the “Big Questions” — realms of science, faith, God and the purpose of humanity. Along the way, he became one of the world’s richest men, gave up American citizenship, moved to the Bahamas, was knighted by the Queen of England and bestowed much of his fortune on spiritual thinkers and innovators: Mother Teresa, Billy Graham, Aleksandr I. Solzhenitsyn, the physicist Freeman Dyson, the philosopher Charles Taylor and a pantheon of Christians, Jews, Muslims, Buddhists and Hindus. Sir John sold the Templeton family of funds — scores of them with $13 billion in assets — in 1992, and turned to philanthropies that had engaged him for decades. While he was an elder of the Presbyterian Church (U.S.A.), he took a broad view of spirituality, espousing non-literal views of heaven and hell and a shared divinity between humanity and God. John Marks Templeton was born on Nov. 29, 1912, in Winchester, a small Tennessee town 60 miles from Dayton, the scene of the 1925 Scopes “monkey trial” pitting Clarence Darrow and William Jennings Bryan in a battle over the theory of evolution versus fundamentalist views of the Creation. The boy was only 12 then, but issues in the case dominated his later life; he wrote at least eight books on spiritual matters. He was raised in a devout household and was one of few students in town to go to college. Supporting himself at Yale in the Depression, he graduated near the top of his class in 1934, won a Rhodes Scholarship to Balliol College at Oxford University and earned a master’s degree in law. He began his Wall Street career in 1937. That year, he married the former Judith Folk. The couple had three children. His wife died in 1951. In 1958, he married Irene Reynolds Butler, who died in 1993. His daughter, Anne Templeton Zimmerman, died in 2005, and a stepson, Malcolm Butler, died in 1995. He is survived by two sons from his first marriage, John M. Jr., of Bryn Mawr, Pa., a retired surgeon and the chairman and president of the Templeton Foundation, and Christopher, of Colfax, Iowa; a stepdaughter, Wendy Brooks, of Delray Beach, Fla., and three grandchildren and three great-grandchildren.