A Washington philanthropist, Sant is president of The Summit Foundation and The Summit Fund of Washington, which she co-founded with her husband, Roger, in 1982. Sant is president of the National Gallery of Art, honorary chair of The Phillips Collection, and a board member of the Foundation for Art and Preservation in Embassies. In addition, she is a member of the International Council of the Museum of Modern Art and of ArtTable. Sant developed her interest in art at Stanford University, where she took art history courses and earned her B.A. in History and Literature.