Born to Eugene C. Pulliam and Martha Pulliam in 1922, she grew up in Indiana, where she attended DePauw University and later married her college sweetheart, James Quayle.
Her father, Eugene C. Pulliam, was a longtime owner and publisher of The Arizona Republic and the Indianapolis Star.
The "Pulliam era" began in Arizona in 1946 when Eugene C. Pulliam bought The Republic, the Phoenix Gazette and the Arizona Weekly Gazette, later the Arizona Business Gazette, in a $4 million deal.
Taking after her father, Quayle and her husband owned and published the Huntington Herald-Press in Huntington, Indiana and later the Wickenburg Sun in Arizona.
Her husband, James Quayle, was World War II veteran whose conservative beliefs heavily influenced those of their politician son, James Danforth "Dan" Quayle. Under his ownership, The Herald-Press was known in Democratic circles as the "The Herald-Suppress" due to Quayle's lack of interest in giving attention to political opponents, according to an article published in The Republic following James Quayle's death in 2000.
Dan Quayle, served as the 44th Vice President of the United States under President George H.W. Bush.
James and Corinne Quayle moved to Wickenburg, Arizona in 1978, where Corinne became a member of the Desert Caballeros Western Museum and a founding member of the Humane Society of Wickenburg.
The Quayle Vice Presidential Learning Center was established in Huntington, Indiana after Dan Quayle's term as vice president.
Corinne Quayle is survived by a sister, Suzanne Murphy, her children: Dan Quayle, Chris Quayle, Martha Thomas and Mike Quayle. She is also survived by 10 grandchildren and 10 great-grandchildren.