Marilu Gorno Tempini

Marilu Gorno Tempini, MD, PhD Professor of Neurology and Psychiatry marialuisa.gornotempini@ucsf.edu +1 415 476-1895 Fields of Interest: LanguageImaging Dr. Maria Luisa Gorno Tempini is a behavioral neurologist and holds the Charles Schwab Endowed Professorship in Dyslexia and Neurodevelopment. She currently directs the Language Neurobiology Laboratory at the UCSF Memory and Aging Center and co-directs the UCSF Dyslexia Center. She obtained her medical degree and clinical neurology specialty training in Italy and has a doctorate in the neuroimaging of language from University College London. Her clinical work concentrates on behavioral neurology across the lifespan, and her research investigates the neural basis of higher cognitive functions such as language and memory. Dr. Gorno Tempini has applied her expertise in cognitive neurology to neurodegenerative diseases, particularly primary progressive aphasia (PPA) and frontotemporal dementia (FTD), and to language-based learning differences, such as dyslexia. In 2011, Dr. Gorno Tempini’s NIH-funded research resulted in new diagnostic criteria for PPA and its variants. In 2014, Dr. Gorno Tempini co-founded the UCSF Dyslexia Center, which aims to classify dyslexia into behavioral phenotypes defined by patterns of neuropsychological strengths and weaknesses. These efforts will lead to more targeted assessments and treatments amongst clinical and educational systems. The UCSF Dyslexia Center brings together neurologists, psychiatrists, biomedical engineers, radiologists, neuropsychologists, speech-language pathologists and research coordinators to discover structural and functional differences in the brains of children and older adults with dyslexia. Dr. Gorno Tempini leads many projects at UCSF and is funded by the NIH and various philanthropic sources. She is particularly dedicated to mentoring and was awarded an NIH K24 grant to mentor interdisciplinary researchers in the field of clinical cognitive neuroscience. Publications Temporal variant of frontotemporal dementia in C9orf72 repeat expansion carriers: two case studies. Brain imaging and behavior Caso F, Agosta F, Magnani G, Cardamone R, Borghesani V, Miller Z, Riva N, La Joie R, Coppola G, Grinberg LT, Seeley WW, Miller BL, Gorno-Tempini ML, Filippi M fMRI-Targeted High-Angular Resolution Diffusion MR Tractography to Identify Functional Language Tracts in Healthy Controls and Glioma Patients. Frontiers in neuroscience Sanvito F, Caverzasi E, Riva M, Jordan KM, Blasi V, Scifo P, Iadanza A, Crespi SA, Cirillo S, Casarotti A, Leonetti A, Puglisi G, Grimaldi M, Bello L, Gorno-Tempini ML, Henry RG, Falini A, Castellano A Speech production differences in English and Italian speakers with nonfluent variant PPA. Neurology Canu E, Agosta F, Battistella G, Spinelli EG, DeLeon J, Welch AE, Mandelli ML, Hubbard HI, Moro A, Magnani G, Cappa SF, Miller BL, Filippi M, Gorno-Tempini ML Task-Free Functional Language Networks: Reproducibility and Clinical Application. The Journal of neuroscience : the official journal of the Society for Neuroscience Battistella G, Borghesani V, Henry M, Shwe W, Lauricella M, Miller Z, Deleon J, Miller BL, Dronkers N, Brambati SM, Seeley WW, Mandelli ML, Gorno-Tempini ML State and trait characteristics of anterior insula time-varying functional connectivity. NeuroImage Pasquini L, Toller G, Staffaroni A, Brown JA, Deng J, Lee A, Kurcyus K, Shdo SM, Allen I, Sturm VE, Cobigo Y, Borghesani V, Battistella G, Gorno-Tempini ML, Rankin KP, Kramer J, Rosen HH, Miller BL, Seeley WW Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy. Neuron Brown JA, Deng J, Neuhaus J, Sible IJ, Sias AC, Lee SE, Kornak J, Marx GA, Karydas AM, Spina S, Grinberg LT, Coppola G, Geschwind DH, Kramer JH, Gorno-Tempini ML, Miller BL, Rosen HJ, Seeley WW Evidence of corticofugal tau spreading in patients with frontotemporal dementia. Acta neuropathologica Kim EJ, Hwang JL, Gaus SE, Nana AL, Deng J, Brown JA, Spina S, Lee MJ, Ramos EM, Grinberg LT, Kramer JH, Boxer AL, Gorno-Tempini ML, Rosen HJ, Miller BL, Seeley WW Semantic and lexical features of words dissimilarly affected by non-fluent, logopenic, and semantic primary progressive aphasia. Journal of the International Neuropsychological Society : JINS Vonk JMJ, Jonkers R, Hubbard HI, Gorno-Tempini ML, Brickman AM, Obler LK Treatment for Word Retrieval in Semantic and Logopenic Variants of Primary Progressive Aphasia: Immediate and Long-Term Outcomes. Journal of speech, language, and hearing research : JSLHR Henry ML, Hubbard HI, Grasso SM, Dial HR, Beeson PM, Miller BL, Gorno-Tempini ML Speech and language therapy approaches to managing primary progressive aphasia. Practical neurology Volkmer A, Rogalski E, Henry M, Taylor-Rubin C, Ruggero L, Khayum R, Kindell J, Gorno-Tempini ML, Warren JD, Rohrer JD Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia. Scientific reports Bonham LW, Steele NZR, Karch CM, Broce I, Geier EG, Wen NL, Momeni P, Hardy J, Miller ZA, Gorno-Tempini ML, Hess CP, Lewis P, Miller BL, Seeley WW, Manzoni C, Desikan RS, Baranzini SE, Ferrari R, Yokoyama JS Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation. Acta neuropathologica Petersen C, Nolan AL, de Paula França Resende E, Miller Z, Ehrenberg AJ, Gorno-Tempini ML, Rosen HJ, Kramer JH, Spina S, Rabinovici GD, Miller BL, Seeley WW, Heinsen H, Grinberg LT Interpersonal prosodic correlation in frontotemporal dementia. Annals of clinical and translational neurology Pressman PS, Ross ED, Cohen KB, Chen KH, Miller BL, Hunter LE, Gorno-Tempini ML, Levenson RW Factors that predict diagnostic stability in neurodegenerative dementia. Journal of neurology Perry DC, Datta S, Miller ZA, Rankin KP, Gorno-Tempini ML, Kramer JH, Rosen HJ, Seeley WW, Miller BL Gyrification abnormalities in presymptomatic c9orf72 expansion carriers. Journal of neurology, neurosurgery, and psychiatry Caverzasi E, Battistella G, Chu SA, Rosen H, Zanto TP, Karydas A, Shwe W, Coppola G, Geschwind DH, Rademakers R, Miller BL, Gorno-Tempini ML, Lee SE Neurocognitive basis of repetition deficits in primary progressive aphasia. Brain and language Lukic S, Mandelli ML, Welch A, Jordan K, Shwe W, Neuhaus J, Miller Z, Hubbard HI, Henry M, Miller BL, Dronkers NF, Gorno-Tempini ML Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain. NeuroImage. Clinical Ossenkoppele R, Iaccarino L, Schonhaut DR, Brown JA, La Joie R, O'Neil JP, Janabi M, Baker SL, Kramer JH, Gorno-Tempini ML, Miller BL, Rosen HJ, Seeley WW, Jagust WJ, Rabinovici GD Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia. Neurocase De Leon J, Mandelli ML, Nolan A, Miller ZA, Mead C, Watson C, Welch AE, Henry ML, Bourakova V, La Joie R, Bajorek LP, Grinberg L, Rabinovici G, Miller BL, Gorno-Tempini ML Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease. Scientific reports Ranasinghe KG, Kothare H, Kort N, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Lee R, Miller BL, Gorno-Tempini ML, Vossel KA, Houde JF, Nagarajan SS Cortical microstructure in the behavioural variant of frontotemporal dementia: looking beyond atrophy. Brain : a journal of neurology Illán-Gala I, Montal V, Borrego-Écija S, Vilaplana E, Pegueroles J, Alcolea D, Sánchez-Saudinós B, Clarimón J, Turón-Sans J, Bargalló N, González-Ortiz S, Rosen HJ, Gorno-Tempini ML, Miller BL, Lladó A, Rojas-García R, Blesa R, Sánchez-Valle R, Lleó A, Fortea J Primary progressive aphasia: a model for neurodegenerative disease. Current opinion in neurology Tee BL, Gorno-Tempini ML Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia. NeuroImage. Clinical Battistella G, Henry M, Gesierich B, Wilson SM, Borghesani V, Shwe W, Miller Z, Deleon J, Miller BL, Jovicich J, Papinutto N, Dronkers NF, Seeley WW, Mandelli ML, Gorno-Tempini ML The Neural Representations of Movement across Semantic Categories. Journal of cognitive neuroscience Borghesani V, Riello M, Gesierich B, Brentari V, Monti A, Gorno-Tempini ML Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers. NeuroImage. Clinical Lee SE, Sias AC, Kosik EL, Flagan TM, Deng J, Chu SA, Brown JA, Vidovszky AA, Ramos EM, Gorno-Tempini ML, Karydas AM, Coppola G, Geschwind DH, Rademakers R, Boeve BF, Boxer AL, Rosen HJ, Miller BL, Seeley WW Investigating the utility of teletherapy in individuals with primary progressive aphasia. Clinical interventions in aging Dial HR, Hinshelwood HA, Grasso SM, Hubbard HI, Gorno-Tempini ML, Henry ML